Intelligent Optimization of a Mixed Culture Cultivation Process

نویسندگان

  • Petia Koprinkova-Hristova
  • Georgi Kostov
  • Silviya Popova
چکیده

In the present paper a neural network approach called “Adaptive Critic Design” (ACD) was applied to optimal tuning of set point controllers of the three main substrates (sugar, nitrogen source and dissolved oxygen) for PHB production process. For approximation of the critic and the controllers a special kind of recurrent neural networks called Echo state networks (ESN) were used. Their structure allows fast training that will be of crucial importance in on-line applications. The critic network is trained to minimize the temporal difference error using Recursive Least Squares method. Two approaches – gradient and heuristic – were exploited for training of the controllers. The comparison is made with respect to achieved improvement of the utility function subject of optimization as well as with known expert strategy for control the PHB production process.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Optimization of secretory expression of recombinant hGM-CSF in high cell density cultivation of recombinant Escherichia coli using Taguchi statistical method

Human granulocyte macrophage colony stimulating factor (hGM-CSF) has many therapeutic applications.In this study, in order to verify the purification process, the effect of carbon source, IPTG concentration andpost-induction time on the secretion of recombinant hGM-CSF into the culture medium by recombinantEscherichia coli during high cell density cultivation were evaluated by...

متن کامل

Optimization of cell mass production of the probiotic strain Lactococcus lactis in batch and fed-bach culture in pilot scale levels

Lactococcus lactis is highly efficient probiotics microorganism with wide range of benefits on human health. This study was conducted to design and establish industrial platform for high cell density cultivation of this novel probiotic strain, L. lactis (WICC-B25). During bioreactor cultivation of lactic acid bacteria in industrial scale, there are two main problems during process namely: low c...

متن کامل

A hybrid approach based on numerical, statistical and intelligent techniques for optimization of tube drawing process to produced squared section from round tube

In the tube drawing process, there are a bunch of parameters which play key role in process performance. Thus, finding the optimized parameters is a controversial issue. Current study aimed to produce a squared section of round tube by tube sinking process. To simulate the process finite element method (FEM) was used. Then, to find a meaningful kinship between process input and output parameter...

متن کامل

Modeling and Simulation of Polyhydroxybutyrate Production by Protomonas extorquens in Fed-batch Culture

Modeling and simulation of Polyhydroxybutyrate (PHB) production by Protomonas extorquens in fed-batch culture were conducted in this research. The fed-batch model, developed for this process, employed a kinetic model proposed by other researchers. Several kinetic models were investigated to choose the best model. The criterion for this selection was goodness of fit (δ2). Haldane kinetic model w...

متن کامل

Intelligent Knowledge Based System Approach for Optimization of Design and Manufacturing Process for Wire-Electrical Discharge Machining

Wire electrical discharge machining (WEDM) is a method to cut conductive materials with a thin electrode that follows a programmed path. The electrode is a thin wire. Typical diameters range from .004" - .012" (.10mm - .30mm) although smaller and larger diameters are available. WEDM is a thermal machining process capable of accurately machining parts with varying hardness or complex shapes. WED...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015